About the Authors

Eric E. Smith

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

eesmith@ucalgary.ca

Affiliations Department of Clinical Neurosciences, University of Calgary, Calgary, Canada, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

Alona Muzikansky

Roles Methodology, Writing – review & editing

Affiliation Department of Biostatistics, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Cheryl R. McCreary

Roles Methodology, Writing – review & editing

Affiliation Department of Radiology, University of Calgary, Calgary, Alberta, Canada

Saima Batool

Roles Investigation, Writing – review & editing

Affiliation Department of Radiology, University of Calgary, Calgary, Alberta, Canada

Anand Viswanathan

Roles Conceptualization, Writing – review & editing

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Bradford C. Dickerson

Roles Resources, Writing – review & editing

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Keith Johnson

Roles Investigation, Resources, Software, Writing – review & editing

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Steven M. Greenberg

Roles Conceptualization, Writing – review & editing

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Deborah Blacker

Roles Conceptualization, Data curation, Project administration, Supervision, Writing – review & editing

Affiliations Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: Dr. Smith reports having received travel expenses and honoraria for lectures and educational activities from the American Heart Association, Alzheimer’s Association and Canadian Conference on Dementia; has served on a Data Safety Monitoring Board for Massachusetts General Hospital; is an Assistant Editor of Stroke; is a member of the Editorial Board of the Journal of the American Heart Association; and has received research funding from the National Institute of Neurological Disorders and Stroke (R01 NS062028), Canadian Institutes of Health Research, Alberta Innovates – Health Solutions, Canadian Partnership Against Cancer, Heart and Stroke Foundation of Alberta, and the Alzheimer Society of Canada. Ms. Muzikansky, Dr. McCreary and Dr. Batool report no potential conflicts of interest. Dr. Viswanathan has served on a Data safety monitoring board for Roche Pharmaceuticals; has consulted for Athena Diagnostics; and has received research support from NIH grants NIA 2P50AG005134-268382 and 1K23AG028726-01A2. Dr. Dickerson reports having received travel expenses and honoraria for lectures and educational activities from the International Neuropsychological Society, American Academy of Neurology, Haymarket Medical Group, MedLearning Group, and Alzheimer’s Association; is serving on a Data Safety Monitoring Board for Merck; is a consultant for Forum Inc, Isis Inc, Piramal Inc, and Best Doctors Inc; is an Associate Editor of Cortex; is a member of the Editorial Board of Hippocampus, Neurodegenerative Disease Management, and Neuroimage: Clinical; has received royalties from Oxford University Press for “Dementia: Comprehensive Principles and Practice” and from Cambridge University Press for “Frontotemporal Dementia”; and has received research funding from the National Institute of Neurological Disorders and Stroke (R21 NS077059, R21-NS084156, R21-NS079905), National Institute of Mental Health (R21-MH097094), National Institute on Aging (R01-AG030311), Tau Consortium, and ALS Association. Dr. Johnson has served as paid consultant for Bayer, Biogen Idec, Bristol-Myers Squibb, GE Healthcare, Isis Pharmaceuticals Inc., Janssen Alzheimer’s Immunotherapy, Piramal, Siemens Medical Solutions, and Genzyme; he is a site principal investigator or coinvestigator for Lilly/Avid, Biogen Idec, Bristol-Myers Squibb, Eisai, Pfizer, Janssen Alzheimer Immunotherapy, Merck, and Navidea clinical trials; he has spoken at symposia sponsored by Janssen Alzheimer’s Immunotherapy, GEHC, Lundbeck, and Pfizer; and he receives research support from NIH grants R01EB014894, R21 AG038994, R01 AG026484, R01 AG034556, P50 AG00513421, U19 AG10483, P01 AG036694, R13 AG042201174210, R01 AG027435, and R01 AG037497. Dr. Greenberg reports having received fees for serving on scientific advisory or data safety monitoring boards from Hoffman-La Roche and Quintiles; funding for travel/speaker honoraria from New York Academy of Sciences, Quebec Society of Vascular Sciences, Cerebral Amyloid Angiopathy conference, European Stroke Conference, and American Academy of Neurology; serves on editorial advisory boards for Neurology, Stroke, Frontiers in Stroke, Cerebrovascular Diseases, and J Alzheimer’s Disease and Other Dementias; receives publishing royalties from UpToDate and Medlink; and research support from NIH (R01AG026484, R01NS070834, U10NS077360). Dr. Blacker reports having received travel expenses and honoraria for lectures and educational activities not funded by industry; is a member of the Editorial Board of Experimental Gerontology; receives research funding from NIA, NIMH, NINCDS, the Alzheimer’s Association, the Alzheimer’s Drug Discovery Foundation, and Fidelity Biosciences. We confirm that the disclosures do not alter our adherence to PLOS ONE policies on sharing data and materials.