About the Authors

Yoko M. Nakao

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft

Affiliation Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Yoshihiro Miyamoto

Roles Data curation, Project administration, Supervision, Writing – review & editing

miyamoty@ncvc.go.jp

Affiliation Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Kenji Ueshima

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Kyoto, Japan

Kazuhiro Nakao

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Michikazu Nakai

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Statistics and Data Analysis, Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Kunihiro Nishimura

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Statistics and Data Analysis, Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Shinji Yasuno

Roles Data curation, Project administration, Writing – review & editing

Current address: Japan Agency for Medical Research and Development, Tokyo, Japan

Affiliation Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Kyoto, Japan

Kiminori Hosoda

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Yoshihiro Ogawa

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

Hiroshi Itoh

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Hisao Ogawa

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Kenji Kangawa

Roles Data curation, Project administration, Supervision, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center, Suita, Osaka, Japan

Kazuwa Nakao

Roles Conceptualization, Data curation, Project administration, Supervision, Writing – review & editing

Affiliation Medical Innovation Center, Kyoto University School of Medicine, Kyoto, Kyoto, Japan

Competing Interests

This work was supported Japan Agency for Medical Research and Development (https://www.amed.go.jp) and the Clinical and Epidemiologic Research of the Joint Project of Japan Heart Foundation and the Japanese Society of Cardiovascular Disease Prevention sponsored by AstraZeneca (http://www.jhf.or.jp/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.