Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation

Pallavi Srivastava; Asitikantha Sarma; Chandra Mohini Chaturvedi

doi:10.1371/journal.pone.0190516

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Open Access

Peer-reviewed

Research Article

Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation

Pallavi Srivastava,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India
⨯
Asitikantha Sarma,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Radiation Biology Laboratory, Inter University Accelerator Centre, New Delhi, India
⨯
Chandra Mohini Chaturvedi

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: cmcbhu@gmail.com

Affiliation Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

http://orcid.org/0000-0001-7788-6557

⨯

Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation

Pallavi Srivastava,
Asitikantha Sarma,
Chandra Mohini Chaturvedi

Published: January 10, 2018
https://doi.org/10.1371/journal.pone.0190516

About the Authors

Pallavi Srivastava

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Asitikantha Sarma

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Radiation Biology Laboratory, Inter University Accelerator Centre, New Delhi, India

Chandra Mohini Chaturvedi

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: cmcbhu@gmail.com

Affiliation Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India

http://orcid.org/0000-0001-7788-6557

Competing Interests

The authors have declared that no competing interests exist.

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Radiation therapy
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Prostate cancer
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Cancer treatment
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Apoptosis
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Cell cycle and cell division
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Lung and intrathoracic tumors
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Cell death
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DNA repair
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