About the Authors

Nahoko Kuga

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Pharmacology Research Laboratory, Watarase Research Center, Kyorin Pharmaceutical Company, Limited, Nogi, Tochigi, Japan

Asao Tanioka

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Pharmacology Research Laboratory, Watarase Research Center, Kyorin Pharmaceutical Company, Limited, Nogi, Tochigi, Japan

Koichiro Hagihara

Roles Conceptualization, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Pharmacology Research Laboratory, Watarase Research Center, Kyorin Pharmaceutical Company, Limited, Nogi, Tochigi, Japan

Tomoyuki Kawai

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

tomoyuki.kawai@mb.kyorin-pharm.co.jp

Affiliation Pharmacology Research Laboratory, Watarase Research Center, Kyorin Pharmaceutical Company, Limited, Nogi, Tochigi, Japan

Competing Interests

NK, AT, KH and TK are employed by Kyorin Pharmaceutical Co., Ltd. This study was also funded by Kyorin Pharmaceutical Co., Ltd. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.