About the Authors

Katharine Victoria Jensen

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

Orsolya Cseh

Roles Data curation

Affiliation Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

Ahmed Aman

Roles Data curation

Affiliation Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

Samuel Weiss

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

Hema Artee Luchman

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

aluchman@ucalgary.ca

Affiliation Hotchkiss Brain Institute and Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada

Competing Interests

A research agreement with Cell Therapeutics Biopharma, reviewed and approved by the Ethics and Legal departments at the University of Calgary and CTI Biopharma, provided partial funding and GMP grade of the drug pacritinib for completion of this study. This does not alter our adherence to PLOS ONE policies on sharing data and materials presented in this manuscript.