About the Authors

Shinichi Saitoh

Roles Data curation, Investigation, Validation, Visualization, Writing – original draft

Affiliation Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Satoshi Okano

Roles Investigation

Affiliation Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Hidekazu Nohara

Roles Investigation

Affiliation Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Hiroshi Nakano

Roles Investigation

Affiliation Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Nobuyuki Shirasawa

Roles Investigation

Affiliation Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Akira Naito

Roles Investigation

Affiliation Department of Anatomy and Structural Science, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Masayuki Yamamoto

Roles Resources

Affiliation Department of Medical Biochemistry, Tohoku University School of Medicine, Sendai, Japan

Vincent P. Kelly

Roles Validation, Writing – review & editing

Affiliation School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

Kiwamu Takahashi

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Validation

Affiliation SBI Pharmaceuticals Co., Ltd., Tokyo, Japan

Tohru Tanaka

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation SBI Pharmaceuticals Co., Ltd., Tokyo, Japan

Motowo Nakajima

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation SBI Pharmaceuticals Co., Ltd., Tokyo, Japan

Osamu Nakajima

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

nakajima@med.id.yamagata-u.ac.jp

Affiliation Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

Competing Interests

SBI Pharmaceuticals Co., Ltd., a sponsor of the study, does not alter our adherence to all PLOS ONE policies on sharing data and materials obtained in this study.