About the Authors

Kesava Asam

Roles Investigation

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America

Agnieszka Staniszewski

Roles Data curation, Investigation

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America

Hong Zhang

Roles Data curation, Investigation

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America

Scott L. Melideo

Roles Investigation

Affiliation Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Adolfo Mazzeo

Roles Investigation

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America

Michael Voronkov

Roles Project administration, Resources

Affiliation Signum Biosciences, 133 Wall Street, Princeton, New Jersey, United States of America

Kristen L. Huber

Roles Investigation, Resources

Affiliation Signum Biosciences, 133 Wall Street, Princeton, New Jersey, United States of America

Eduardo Pérez

Roles Project administration, Writing – review & editing

Affiliation Signum Biosciences, 133 Wall Street, Princeton, New Jersey, United States of America

Maxwell Stock

Roles Conceptualization, Funding acquisition

Affiliation Signum Biosciences, 133 Wall Street, Princeton, New Jersey, United States of America

Jeffry B. Stock

Roles Conceptualization, Writing – review & editing

Affiliations Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, Signum Biosciences, 133 Wall Street, Princeton, New Jersey, United States of America

Ottavio Arancio

Roles Conceptualization, Writing – review & editing

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America, Department of Medicine, Columbia University, New York, NY, United States of America

Russell E. Nicholls

Roles Conceptualization, Formal analysis, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

rn95@columbia.edu

Affiliations Department of Pathology and Cell Biology, Columbia University, New York, NY, United States of America, The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, United States of America

Competing Interests

JBS is a founder of Signum Biosciences, Inc., which employs the indicated coauthors. Signum Biosciences is the owner or exclusive licensee of various patents (including US Patent Nos. 7,923,041, 8,221,804, and 9,486,441) and patent applications covering compositions that contain tryptamides such as eicosanoyl-5-hydroxytryptamide (E5HT), as well as methods for making and using such compositions. In addition, Signum Biosciences has licensed its proprietary EHT® coffee extract, which contains E5HT, for sale in the United States and other countries. This does not alter our adherence to PLOS ONE policies on sharing data and materials.