About the Authors

Sabina Eigenbrod

Roles Investigation

Current address: Servier Deutschland GmbH, Munich, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Petra Frick

Roles Investigation, Writing – original draft, Writing – review & editing

petra.frick@dzne.de

Current address: German Center for Neurodegenerative Diseases, Tübingen, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Uwe Bertsch

Roles Formal analysis, Investigation

Current address: Louisenlund School, Güby, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Gerda Mitteregger-Kretzschmar

Roles Investigation, Writing – original draft, Writing – review & editing

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Janina Mielke

Roles Investigation

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Marko Maringer

Roles Investigation

Current address: MFD Diagnostic GmbH, Wendelsheim, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Niklas Piening

Roles Investigation

Current address: BASF SE, Ludwigshafen, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Alexander Hepp

Roles Investigation

Current address: Klenze Secondary School Munich, Munich, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Nathalie Daude

Roles Investigation, Writing – review & editing

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Otto Windl

Roles Writing – review & editing

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Johannes Levin

Roles Investigation

Current address: Department of Neurology, University Hospital Munich, Munich, Germany

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Armin Giese

Roles Conceptualization, Investigation

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

Vignesh Sakthivelu

Roles Investigation

Current address: Present address, Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases CECAD, University Cologne, Cologne, Germany

Affiliation Department of Metabolic Biochemistry/Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany

Jörg Tatzelt

Roles Investigation

Current address: Department of Biochemistry of Neurodegenerative Diseases, Ruhr University Bochum, Bochum, Germany

Affiliation Department of Metabolic Biochemistry/Neurobiochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany

Hans Kretzschmar

† Deceased.

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

Affiliation Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany

David Westaway

Roles Writing – review & editing

Affiliation Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Competing Interests

The authors have read the journal's policy and have the following conflicts: after finalizing the experiments, three of the authors left the ZNP and are currently employed by commercial companies: Servier Deutschland GmbH (SE), MFD Diagnostic GmbH (MM), and BASF (NP). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.