About the Authors

Young Tae Kim

Contributed equally to this work with: Young Tae Kim, Byung Keun Park

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Byung Keun Park

Contributed equally to this work with: Young Tae Kim, Byung Keun Park

Roles Data curation, Formal analysis, Investigation, Methodology

Current address: Jang Sang Doraji Co., Jinju, Republic of Korea

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Sung Eun Kim

Roles Formal analysis, Investigation, Methodology

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Won Jung Lee

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Jae Sun Moon

Roles Data curation, Investigation, Software, Writing – review & editing

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Min Seop Cho

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation Green Biotech Co., Paju, Republic of Korea

Ho-Yong Park

Roles Data curation, Formal analysis, Resources

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Ingyu Hwang

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

kimsu@kribb.re.kr (SUK); ingyu@snu.ac.kr (IH)

Affiliation Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea

Sung Uk Kim

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

kimsu@kribb.re.kr (SUK); ingyu@snu.ac.kr (IH)

Current address: Department of Food Science and Engineering, Seowon University, Cheongju, Republic of Korea

Affiliation Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea

Competing Interests

Min Seop Cho is employed by Green Biotech Co. who participated in our project as a cooperative research institute by performing the large-scale fermentation and in vivo field test. Min Seop Cho contributed to this study by providing research materials and adding to the Discussion of the manuscript. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.