Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation

• Vishal Koparde ,

  Contributed equally to this work with: Vishal Koparde, Badar Abdul Razzaq

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft

  Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Badar Abdul Razzaq ,

  Contributed equally to this work with: Vishal Koparde, Badar Abdul Razzaq

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Tara Suntum,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Roy Sabo,

  Roles Formal analysis, Validation, Writing – original draft

  Affiliation Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Allison Scalora,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Myrna Serrano,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft

  Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Max Jameson-Lee,

  Roles Conceptualization, Methodology, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Charles Hall,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• David Kobulnicky,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Nihar Sheth,

  Roles Data curation, Methodology, Software, Writing – original draft

  Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Juliana Feltz,

  Roles Conceptualization, Methodology, Writing – original draft

  Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Daniel Contaifer Jr.,

  Roles Formal analysis, Writing – review & editing

  Affiliation School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Dayanjan Wijesinghe,

  Roles Formal analysis, Writing – review & editing

  Affiliation School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Jason Reed,

  Roles Formal analysis, Validation, Writing – original draft

  Affiliation Department of Physics, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Catherine Roberts,

  Roles Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Rehan Qayyum,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Section of Hospital Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Gregory Buck,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft

  Affiliations Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Michael Neale,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  Affiliation Departments of Psychiatry and Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America

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•  [ ... ],
• Amir Toor

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft

  * E-mail: amir.toor@vcuhealth.org

  Affiliation Bone Marrow Transplant Program, Department of Internal Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

  http://orcid.org/0000-0001-5317-8433

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