About the Authors

Laetitia Canini

Contributed equally to this work with: Laetitia Canini, Michio Imamura

Roles Formal analysis, Funding acquisition, Methodology, Writing – original draft

Affiliations The program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom

Michio Imamura

Contributed equally to this work with: Laetitia Canini, Michio Imamura

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

Yoshiiku Kawakami

Roles Data curation

Affiliation Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

Susan L. Uprichard

Roles Funding acquisition, Writing – review & editing

Affiliation The program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America

Scott J. Cotler

Roles Writing – review & editing

Affiliation The program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America

Harel Dahari

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft

chayama@mba.ocn.ne.jp (KC); hdahari@luc.edu (HD)

Affiliation The program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America

Kazuaki Chayama

Roles Conceptualization, Data curation, Methodology, Supervision, Writing – review & editing

chayama@mba.ocn.ne.jp (KC); hdahari@luc.edu (HD)

Affiliation Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

Competing Interests

K.C. received honoraria from Otsuka, Dainippon Sumitomo Pharma, AbbVie, Gilead Sciences Inc., and Bristol-Myers Squibb. MSD, K.K., and M.I. received research funding from Bristol-Myers Squibb. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare.