Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2

Kelly R. VanDenBerg; Robert A. Freeborn; Sheng Liu; Rebekah C. Kennedy; Joseph W. Zagorski; Cheryl E. Rockwell

doi:10.1371/journal.pone.0185579

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Peer-reviewed

Research Article

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2

Kelly R. VanDenBerg ,

Contributed equally to this work with: Kelly R. VanDenBerg, Robert A. Freeborn

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Robert A. Freeborn ,

Contributed equally to this work with: Kelly R. VanDenBerg, Robert A. Freeborn

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Sheng Liu,

Roles Investigation, Methodology

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Rebekah C. Kennedy,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Joseph W. Zagorski,

Roles Investigation, Methodology, Supervision

Affiliations Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, United States of America
⨯
Cheryl E. Rockwell

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: rockwelc@msu.edu

Affiliations Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, United States of America

http://orcid.org/0000-0002-0987-3460

⨯

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2

Kelly R. VanDenBerg,
Robert A. Freeborn,
Sheng Liu,
Rebekah C. Kennedy,
Joseph W. Zagorski,
Cheryl E. Rockwell

Published: October 19, 2017
https://doi.org/10.1371/journal.pone.0185579

About the Authors

Kelly R. VanDenBerg

Contributed equally to this work with: Kelly R. VanDenBerg, Robert A. Freeborn

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Robert A. Freeborn

Contributed equally to this work with: Kelly R. VanDenBerg, Robert A. Freeborn

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Sheng Liu

Roles Investigation, Methodology

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Rebekah C. Kennedy

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America

Joseph W. Zagorski

Roles Investigation, Methodology, Supervision

Affiliations Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, United States of America

Cheryl E. Rockwell

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: rockwelc@msu.edu

Affiliations Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, United States of America, Cell and Molecular Biology Program, Michigan State University, East Lansing, Michigan, United States of America

http://orcid.org/0000-0002-0987-3460

Competing Interests

The authors have declared that no competing interests exist.

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T cells
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Cytokines
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Arsenic
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Messenger RNA
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Transcription factors
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Cytokine therapy
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Gene expression
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Secretion
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