About the Authors

Kenji Toyoshima

Contributed equally to this work with: Kenji Toyoshima, Marie Nakamura

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

k.toyoshima.vasc@tmd.ac.jp

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Marie Nakamura

Contributed equally to this work with: Kenji Toyoshima, Marie Nakamura

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Yusuke Adachi

Roles Resources

Affiliation Institute for Innovation, Ajinomoto, Corartion, Incprporated, Kawasaki-shi, Kanagawa, Japan

Akira Imaizumi

Roles Resources

Affiliation Institute for Innovation, Ajinomoto, Corartion, Incprporated, Kawasaki-shi, Kanagawa, Japan

Tomomi Hakamada

Roles Data curation, Investigation, Resources

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Yasuko Abe

Roles Data curation, Investigation, Methodology, Project administration, Resources

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Eiji Kaneko

Roles Data curation, Investigation

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Soiciro Takahashi

Roles Data curation, Investigation, Resources

Affiliation Mituke Municipal Hospital, Mistuke-shi, Niigata, Japan

Kentaro Shimokado

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

Competing Interests

Yusuke Adachi and Akira Imaizumi are employees of Ajinomoto, Co., Inc. The funder provided support in the form of salaries for authors [YA, AI], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. None of the other co-authors has any conflicts of interest to declare.