An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of FMO2*1

Ephrem Mekonnen; Endashaw Bekele

doi:10.1371/journal.pone.0184931

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Open Access

Peer-reviewed

Research Article

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of *FMO2**1

Ephrem Mekonnen ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ephrememuti@gmail.com, ephremephraim@yahoo.com

Affiliations Department of Microbial, Cellular, Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia, Department of Health Biotechnology, Institute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Endashaw Bekele

Roles Project administration, Supervision, Validation, Writing – original draft

Affiliation Department of Microbial, Cellular, Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia
⨯

An ancestral human genetic variant linked to an ancient disease: A novel association of FMO2 polymorphisms with tuberculosis (TB) in Ethiopian populations provides new insight into the differential ethno-geographic distribution of *FMO2**1

Ephrem Mekonnen,
Endashaw Bekele

Published: October 5, 2017
https://doi.org/10.1371/journal.pone.0184931

About the Authors

Ephrem Mekonnen

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ephrememuti@gmail.com, ephremephraim@yahoo.com

Affiliations Department of Microbial, Cellular, Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia, Department of Health Biotechnology, Institute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia

Endashaw Bekele

Roles Project administration, Supervision, Validation, Writing – original draft

Affiliation Department of Microbial, Cellular, Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia

Competing Interests

The authors have declared that no competing interests exist.

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Tuberculosis
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Haplotypes
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Single nucleotide polymorphisms
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Medical risk factors
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Alleles
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Genetics of disease
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Mycobacterium tuberculosis
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Immune response
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