Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

Jinsung Hong; Sricharan Murugesan; Eric Betzig; John A. Hammer

doi:10.1371/journal.pone.0183174

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Open Access

Peer-reviewed

Research Article

Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

Jinsung Hong,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America
⨯
Sricharan Murugesan,

Roles Conceptualization, Writing – original draft

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America
⨯
Eric Betzig,

Roles Resources

Affiliation Janelia Research Campus/HHMI, Ashburn, VA, United States of America
⨯
John A. Hammer

Roles Conceptualization, Funding acquisition, Resources, Writing – original draft

* E-mail: hammerj@nhlbi.nih.gov,

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America
⨯

Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

Jinsung Hong,
Sricharan Murugesan,
Eric Betzig,
John A. Hammer

Published: August 17, 2017
https://doi.org/10.1371/journal.pone.0183174

About the Authors

Jinsung Hong

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America

Sricharan Murugesan

Roles Conceptualization, Writing – original draft

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America

Eric Betzig

Roles Resources

Affiliation Janelia Research Campus/HHMI, Ashburn, VA, United States of America

John A. Hammer

Roles Conceptualization, Funding acquisition, Resources, Writing – original draft

* E-mail: hammerj@nhlbi.nih.gov,

Affiliation Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America

Competing Interests

The authors have declared that no competing interests exist.

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T cells
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Myosins
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Actins
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Phosphorylation
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TCR signaling cascade
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Cell staining
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Cytotoxic T cells
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Flow cytometry
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