About the Authors

Kohei Murakami

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation

Affiliations Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan, Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano, Japan, Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, Japan

Yasuhiro Kobayashi

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft

Affiliation Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano, Japan

Shunsuke Uehara

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, Japan

Takako Suzuki

Roles Formal analysis

Affiliation Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Masanori Koide

Roles Formal analysis, Writing – review & editing

Affiliation Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano, Japan

Teruhito Yamashita

Roles Formal analysis

Affiliation Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano, Japan

Midori Nakamura

Roles Formal analysis

Affiliation Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, Japan

Naoyuki Takahashi

Roles Formal analysis, Writing – review & editing

Affiliation Institute for Oral Science, Matsumoto Dental University, Shiojiri, Nagano, Japan

Hiroyuki Kato

Roles Resources

Affiliation Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Nobuyuki Udagawa

Roles Formal analysis

Affiliation Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, Japan

Yukio Nakamura

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

yxn14@aol.jp

Affiliation Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

Competing Interests

The author YN received a funding from a commercial source: Eli Lilly and Company. The authors do not have any other relevant declarations relating to employment, consultancy, patents, products in development, marketed products, etc. The authors declare that they have no other financial or nonfinancial, professional, or personal potential competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.