Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs

Lizhi Cao; Robert Lafyatis; Linda C. Burkly

doi:10.1371/journal.pone.0180751

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Open Access

Peer-reviewed

Research Article

Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs

Lizhi Cao ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lizhicao1986@gmail.com

Affiliation Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0003-3725-0057

⨯
Robert Lafyatis,

Roles Resources, Validation, Writing – review & editing

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Linda C. Burkly

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, United States of America
⨯

Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs

Lizhi Cao,
Robert Lafyatis,
Linda C. Burkly

Published: June 29, 2017
https://doi.org/10.1371/journal.pone.0180751

About the Authors

Lizhi Cao

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lizhicao1986@gmail.com

Affiliation Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, United States of America

http://orcid.org/0000-0003-3725-0057

Robert Lafyatis

Roles Resources, Validation, Writing – review & editing

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Linda C. Burkly

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Neuroimmunology, Biogen, Cambridge, Massachusetts, United States of America

Competing Interests

The authors (LC and LB) are employees of Biogen. This affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.

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Collagens
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Sequence alignment
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Fibroblasts
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Cell migration
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Dermis
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Gene expression
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Fibrosis
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Biopsy
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