About the Authors

Nada M. S. Al-Saffar

Nada.Al-Saffar@icr.ac.uk

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Alice Agliano

Contributed equally to this work with: Alice Agliano, Lynley V. Marshall

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Lynley V. Marshall

Contributed equally to this work with: Alice Agliano, Lynley V. Marshall

Affiliations Divisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, Divisions of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

L. Elizabeth Jackson

Current address: Retired.

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Geetha Balarajah

Current address: The Centre for Molecular Pathology, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Jasmin Sidhu

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Paul A. Clarke

Affiliation Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom

Chris Jones

Affiliation Divisions of Cancer Therapeutics and Molecular Pathology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Paul Workman

Affiliation Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom

Andrew D. J. Pearson

Current address: Retired.

Affiliation Divisions of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Martin O. Leach

Affiliation Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom

Competing Interests

N.M.S.A, A.A, L.E.J, G.B, J.S, P.A.C, C.J, A.D.J.P, P.W and M.O.L are employees of The Institute of Cancer Research, which has a commercial interest in the development of PI3K inhibitors, and operates a Rewards to Inventors scheme. P.W and P.A.C have been involved in a commercial collaboration with Yamanouchi (now Astellas Pharma) and with Piramed Pharma and intellectual property arising from the program has been licensed to Genentech. Genentech and Piramed Pharma were acquired by Roche. P.W was a founder of, consultant to, and Scientific Advisory Board member of Piramed Pharma (acquired by Roche); was a founder of, consultant to and Scientific Advisory Board and Main Board member of Chroma Therapeutics; is a Consultant/ Scientific Advisory Board member to Nextech Ventures, Astex Pharmaceuticals and Wilex Oncology; and was formerly an employee of AstraZeneca. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: NMSA LVM. Data curation: NMSA. Formal analysis: NMSA AA LVM. Funding acquisition: NMSA LVM MOL CJ. Investigation: NMSA AA LVM LEJ GB JS. Methodology: NMSA AA LVM PAC CJ. Project administration: NMSA. Resources: NMSA LVM MOL CJ ADJP. Supervision: NMSA MOL CJ ADJP PAC PW. Validation: NMSA AA. Visualization: NMSA AA. Writing – original draft: NMSA. Writing – review & editing: NMSA AA LVM LEJ GB JS MOL CJ ADJP PAC PW.