About the Authors

Eugene P. Magennis

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Nora Francini

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation School of Medicine, University of Nottingham, Nottingham, United Kingdom

Francesca Mastrotto

Roles Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft

Affiliations School of Pharmacy, University of Nottingham, Nottingham, United Kingdom, Department of Pharmaceutical and Pharmacological Science, University of Padova, Padova, Italy

Rosa Catania

Roles Investigation, Methodology

Affiliation School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Martin Redhead

Roles Investigation, Methodology

Affiliation School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Francisco Fernandez-Trillo

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliation School of Chemistry, Haworth Building, University of Birmingham, Edgbaston, Birmingham, United Kingdom

David Bradshaw

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, United Kingdom

David Churchley

Roles Conceptualization, Project administration, Resources, Supervision

Affiliation GlaxoSmithKline, St Georges Avenue, Weybridge, Surrey, United Kingdom

Klaus Winzer

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliation BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Cameron Alexander

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

cameron.alexander@nottingham.ac.uk (CA); giuseppe.mantovani@nottingham.ac.uk (GM)

Affiliation School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Giuseppe Mantovani

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

cameron.alexander@nottingham.ac.uk (CA); giuseppe.mantovani@nottingham.ac.uk (GM)

Affiliation School of Pharmacy, University of Nottingham, Nottingham, United Kingdom

Competing Interests

The authors of this manuscript have the following competing interests: two co-authors (D. C. and D. B.) are employed by GlaxoSmithKline. This does not alter their adherence to PLOS ONE policies on sharing data and materials.