About the Authors

Masato Miyake

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – review & editing

Affiliations Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan, Department of Molecular Research, Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan, Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan

Masashi Kuroda

Roles Formal analysis

Affiliation Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

Hiroshi Kiyonari

Roles Resources

Affiliation Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies, Kobe, Japan

Kenji Takehana

Roles Formal analysis, Validation

Affiliation Department of R&D planning, EA Pharma Co.,Ltd., Tokyo, Japan

Satoshi Hisanaga

Roles Formal analysis

Affiliation Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

Masatoshi Morimoto

Roles Formal analysis

Affiliation Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

Jun Zhang

Roles Formal analysis

Affiliations Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan, Department of Molecular Research, Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan

Miho Oyadomari

Roles Resources

Affiliations Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan, Department of Molecular Research, Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan

Hiroshi Sakaue

Roles Methodology, Supervision

Affiliations Department of Molecular Research, Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan, Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

Seiichi Oyadomari

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

oyadomar@tokushima-u.ac.jp

Affiliations Division of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan, Department of Molecular Research, Diabetes Therapeutics and Research Center, Tokushima University, Tokushima, Japan, Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan

Competing Interests

KT is employed by EA Pharma Co., Ltd. This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.