About the Authors

Nobuhiro Iwakura

Affiliations Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Takeshi Yokoyama

Affiliation Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Yokohama, Japan

Fabio Quaglia

Affiliations Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, University of Camerino, School of Biosciences and Veterinary Medicine, Camerino, Italy

Kaoru Mitsuoka

Affiliation Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Osaka, Japan

Kazuhiro Mio

Affiliation Molecular Profiling Research Center for Drug Discovery and OPERANDO Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

Hideki Shigematsu

Affiliation Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Yokohama, Japan

Mikako Shirouzu

Affiliation Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Yokohama, Japan

Akira Kaji

hideko.kaji@jefferson.edu (HK); kaji@mail.med.upenn.edu (AK)

Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Hideko Kaji

hideko.kaji@jefferson.edu (HK); kaji@mail.med.upenn.edu (AK)

Affiliation Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: AK HK. Data curation: FQ TY NI. Formal analysis: FQ TY NI K. Mitsuoka K. Mio HS MS AK HK. Funding acquisition: AK HK. Investigation: FQ TY NI K. Mitsuoka K. Mio HS MS AK HK. Methodology: FQ TY NI. Project administration: AK HK K. Mitsuoka MS. Resources: MS K. Mitsuoka AK HK. Software: FQ TY. Supervision: K. Mitsuoka MS AK HK. Validation: K. Mitsuoka MS AK HK. Visualization: FQ TY. Writing – original draft: FQ TY NI AK HK. Writing – review & editing: FQ TY AK HK.