About the Authors

Heike J. Wobst

Contributed equally to this work with: Heike J. Wobst, Louise Delsing

Affiliation AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America

Louise Delsing

Contributed equally to this work with: Heike J. Wobst, Louise Delsing

Affiliations AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America, AstraZeneca, Discovery Science, Innovative Medicines and Early Development Biotech Unit, Mölndal, Sweden

Nicholas J. Brandon

Affiliations AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America, AstraZeneca, Neuroscience, Innovative Medicines and Early Development, Waltham, MA, United States of America

Stephen J. Moss

Stephen.Moss@Tufts.edu

Affiliations AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States of America

Competing Interests

SJM serves as a consultant for AstraZeneca and SAGE Therapeutics in relationships that are regulated by Tufts University and do not impact on this study. NJB is a full-time employee and shareholder in AstraZeneca. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: HJW NJB SJM. Formal analysis: HJW LD. Investigation: HJW LD. Methodology: HJW. Supervision: HJW NJB SJM. Validation: HJW LD. Visualization: HJW LD. Writing – original draft: HJW. Writing – review & editing: HJW LD NJB SJM.