About the Authors

Lucia Abela

Affiliations Division of Child Neurology, University Children’s Hospital Zurich, Zurich, Switzerland, Children’s Research Centre, University Children’s Hospital Zurich, Zurich, Switzerland, Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland

Ronen Spiegel

Affiliation Department of Pediatrics B, Emek Medical Center, Afula, Rappaport Faculty of Medicine, Technion, Israel

Lisa M. Crowther

Affiliations Division of Child Neurology, University Children’s Hospital Zurich, Zurich, Switzerland, Children’s Research Centre, University Children’s Hospital Zurich, Zurich, Switzerland, Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland

Andrea Klein

Current address: Pediatric Neurology, University of Basel Children’s Hospital, Basel, Switzerland

Affiliation Division of Child Neurology, University Children’s Hospital Zurich, Zurich, Switzerland

Katharina Steindl

Affiliations Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland, Institute of Medical Genetics, University of Zurich, Schlieren, Switzerland

Sorina Mihaela Papuc

Affiliations Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland, Institute of Medical Genetics, University of Zurich, Schlieren, Switzerland

Pascal Joset

Affiliations Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland, Institute of Medical Genetics, University of Zurich, Schlieren, Switzerland

Yoav Zehavi

Affiliation Department of Pediatrics B, Emek Medical Center, Afula, Rappaport Faculty of Medicine, Technion, Israel

Anita Rauch

Affiliations Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland, Institute of Medical Genetics, University of Zurich, Schlieren, Switzerland

Barbara Plecko

Affiliations Division of Child Neurology, University Children’s Hospital Zurich, Zurich, Switzerland, Children’s Research Centre, University Children’s Hospital Zurich, Zurich, Switzerland, Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland

Thomas Luke Simmons

lukes@evolva.com

Current address: Evolva AG, Reinach, Switzerland

Affiliations Division of Child Neurology, University Children’s Hospital Zurich, Zurich, Switzerland, Children’s Research Centre, University Children’s Hospital Zurich, Zurich, Switzerland, Radiz–Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Zurich, Switzerland

Competing Interests

TLS is a current employee of Evolva AG, which claims no participation or interests in the study or its outcome. TLS has received financial support from Novartis Inc. There are no patents, products in development or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors declare no competing interests.

Author Contributions

Conceptualization: BP AR TLS. Data curation: LA LC KS SMP PJ TLS. Formal analysis: LA RS AK KS YZ AR BP TLS. Funding acquisition: BP AR TLS. Investigation: LA AR BP TLS. Methodology: LA RS LMC KS AR BP TLS. Project administration: AR BP. Resources: AR BP. Software: PJ TLS. Supervision: AR BP. Visualization: LA LMC PJ TLS. Writing – original draft: LA LMC BP TLS. Writing – review & editing: LA LMC BP TLS.