About the Authors

Naomi E. Hammond

nhammond@georgeinstitute.org.au

Affiliations Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia, Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia, Sydney Medical School, University of Sydney, Sydney, Australia, St George Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia

Colman Taylor

Affiliations Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia, Sydney Medical School, University of Sydney, Sydney, Australia

Simon Finfer

Affiliations Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia, Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia, Sydney Medical School, University of Sydney, Sydney, Australia

Flavia R. Machado

Affiliation Anesthesiology, Pain and Intensive Care Department, Federal University of Sao Paulo, Sao Paulo, Brazil

YouZhong An

Affiliation Department of Critical Care Medicine, Peking University People’s Hospital, Beijing, China

Laurent Billot

Affiliations Sydney Medical School, University of Sydney, Sydney, Australia, Statistics Division, The George Institute for Global Health, Sydney, Australia

Frank Bloos

Affiliation Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany

Fernando Bozza

Affiliation D'Or Institute for Research and Education, Rio de Janeiro, Brazil

Alexandre Biasi Cavalcanti

Affiliation Research Institute, Hospital do Coração, São Paulo, Brazil

Maryam Correa

Affiliation Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia

Bin Du

Affiliation Medical Intensive Care Unit, Peking Union Medical College Hospital, Beijing, China

Peter B. Hjortrup

Affiliation Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark

Yang Li

Affiliation Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia

Lauralyn McIntryre

Affiliation Department of Medicine (Critical Care), The Ottawa Hospital Research Institute, Ottawa, Canada

Manoj Saxena

Affiliations Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia, St George Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia, Department of Intensive Care Medicine, St. George Hospital, Sydney, Australia

Frédérique Schortgen

Affiliation Assistance Publique-Hôpitaux de Paris, Réanimation Médicale Groupe Hospitalier Henri Mondor, Créteil, France

Nicola R. Watts

Affiliation Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia

John Myburgh

Affiliations Critical Care and Trauma Division, The George Institute for Global Health, Sydney, Australia, St George Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia, Department of Intensive Care Medicine, St. George Hospital, Sydney, Australia

for the Fluid-TRIPS and Fluidos Investigators

The Fluid-TRIPS and Fluidos Site-based Investigators are listed in the Acknowledgments

The George Institute for Global Health, The ANZICS Clinical Trials Group, BRICNet, and the REVA research Network

Competing Interests

NH, CT, SF, MC, LY, MS, NW, and JM report grants from Baxter HealthCare and CSL Behring paid to their Institute, The George Institute for Global Health in relation to the work submitted. CT reports personal fees from Optum (secondary place of employment), outside the submitted work; SF and JM report honorarium paid to The George Institute for Global Health for consulting to Baxter HealthCare; FB reports lecture honorary from CLS Behring, Germany (supplies human albumin); All other authors report no conflict of interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: NH CT JM SF. Formal analysis: YL LB NH CT. Funding acquisition: NH SF JM. Investigation: NH SF JM MS FM ABC F. Bozza BD YA LM F. Bloss PH FS. Methodology: NH CT JM SF LB. Project administration: NH MC FM ABC YA BD LM F. Bloss PH FS. Resources: NH CT MC NW FM ABC F. Bozza. Software: LB YL NW. Writing – original draft: NH. Writing – review & editing: NH CT SF FM YA LB F. Bloss F. Bozza ABC MC BD PH YL LM MS FS NW JM.