About the Authors

Carrie P. Aaron

cp2346@columbia.edu

Affiliation Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America

Eric A. Hoffman

Affiliation Department of Radiology, University of Iowa, Iowa City, IA, United States of America

Joao A. C. Lima

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Steven M. Kawut

Affiliation Departments of Medicine and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America

Alain G. Bertoni

Affiliation Departments of Medicine and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, NC, United States of America

Jens Vogel-Claussen

Affiliations Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Department of Radiology, Hannover Medical School, Hannover, Germany

Mohammadali Habibi

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Katja Hueper

Affiliations Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Department of Radiology, Hannover Medical School, Hannover, Germany

David R. Jacobs Jr

Affiliation Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, United States of America

Ravi Kalhan

Affiliation Asthma and COPD Program, Northwestern University Feinberg School of Medicine, Chicago, IL, United States of America

Erin D. Michos

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America

Wendy S. Post

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America

Martin R. Prince

Affiliation Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America

Benjamin M. Smith

Affiliations Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America, Department of Medicine, McGill University Health Center, Montreal, QC, Canada

Bharath Ambale-Venkatesh

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Chia-Ying Liu

Affiliations Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Radiology and Imaging Sciences, National Institutes of Health/Clinical Center; Bethesda, MD, United States of America

Filip Zemrak

Affiliation Radiology and Imaging Sciences, National Institutes of Health/Clinical Center; Bethesda, MD, United States of America

Karol E. Watson

Affiliation Department of Medicine, University of California, Los Angeles, CA, United States of America

Matthew Budoff

Affiliation Department of Medicine, University of California, Los Angeles, CA, United States of America

David A. Bluemke

Affiliation Radiology and Imaging Sciences, National Institutes of Health/Clinical Center; Bethesda, MD, United States of America

R. Graham Barr

Affiliations Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States of America, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America

Competing Interests

Dr. Aaron reports research grants from the Alpha-1 Foundation and Stony Wold-Herbert Fund. Dr. Hoffman is a founder and shareholder of VIDA Diagnostics, a company commercializing lung image analysis software developed in part at the University of Iowa. Dr. Kawut reports unrestricted educational grants to his institution from Actelion, United Therapeutic, Gilead, Lung Biotech, Pfizer, Ikaria, Merck, Bayer and the Pulmonary Hypertension Association, grant support from Actelion, Gilead and GeNO, travel reimbursement from the American College of Chest Physicians and the American Thoracic Society, and personal fees from the European Respiratory Journal. Dr. Vogel-Claussen has received personal fees from Novartis and Boehringer Ingelheim. Dr. Hueper has participated in research with Seimens Healthcare and received grant support from Deutsche Forschungsgemeinschaft. Dr. Kalhan has received grant support from Boehringer Ingelheim, GlaxoSmithKline, PneumRx/BTG and Spiration and personal fees from Forest Laboratories, Boehringer Ingelheim and Merck. Dr. Prince has patent agreements with GE Healthcare, Siemens, and Bayer. Dr. Ambale-Venkatesh has received personal fees from Biomet. Dr. Budoff reports grant support from GE. Dr. Barr reports research grants from the Alpha-1 Foundation and personal fees from UpToDate. The other authors report no conflicts. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: CPA EAH JACL DAB RGB. Data curation: EAH JACL AGB JVC MH KH EDM WSP MRP BAV CYL FZ KEW MB DAB RGB. Formal analysis: CPA RGB. Funding acquisition: EAH JACL WSP MB DAB RGB. Investigation: EAH JACL SMK AGB DRJ RK EDM WSP KEW MB DAB RGB. Methodology: EAH JACL JVC MH KH MRP BMS BAV CYL FZ DAB RGB. Software: EAH JVC. Supervision: RGB. Writing – original draft: CPA. Writing – review & editing: CPA EAH JACL SMK AGB JVC MH KH DRJ RK EDM WSP MRP BMS BAV CYL FZ KEW MB DAB RGB.