Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 IVF-ICSI cycles

Vinay Gunnala; Alexis Melnick; Mohamad Irani; David Reichman; Glenn Schattman; Owen Davis; Zev Rosenwaks

doi:10.1371/journal.pone.0176019

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Peer-reviewed

Research Article

Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 IVF-ICSI cycles

Vinay Gunnala ,

* E-mail: vig9035@med.cornell.edu

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

http://orcid.org/0000-0003-4231-6989

⨯
Alexis Melnick ,

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯
Mohamad Irani ,

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯
David Reichman ,

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯
Glenn Schattman ,

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯
Owen Davis ,

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯
Zev Rosenwaks

Current address: Department of Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America
⨯

Sliding scale HCG trigger yields equivalent pregnancy outcomes and reduces ovarian hyperstimulation syndrome: Analysis of 10,427 IVF-ICSI cycles

Vinay Gunnala,
Alexis Melnick,
Mohamad Irani,
David Reichman,
Glenn Schattman,
Owen Davis,
Zev Rosenwaks

Published: April 25, 2017
https://doi.org/10.1371/journal.pone.0176019

About the Authors

Vinay Gunnala

* E-mail: vig9035@med.cornell.edu

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

http://orcid.org/0000-0003-4231-6989

Alexis Melnick

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

Mohamad Irani

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

David Reichman

Contributed equally to this work with: Alexis Melnick, Mohamad Irani, David Reichman

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

Glenn Schattman

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

Owen Davis

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

Zev Rosenwaks

Current address: Department of Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

¶‡ These authors also contributed equally to this work.

Affiliation The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: VG AM DR. Data curation: VG MI. Formal analysis: VG AM MI DR. Visualization: VG AM DR. Writing – original draft: VG AM. Writing – review & editing: AM DR GS OD ZR.

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Oocytes
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Pregnancy
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Medical risk factors
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Fertilization
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Embryos
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Body mass index
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Gonadotropins
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GnRH stimulation test
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