PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia

Kristy R. Howell; Kirsten Floyd; Amanda J. Law

doi:10.1371/journal.pone.0175993

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Open Access

Peer-reviewed

Research Article

PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia

Kristy R. Howell,

Affiliation Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America

http://orcid.org/0000-0002-0872-5335

⨯
Kirsten Floyd,

Affiliation Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America
⨯
Amanda J. Law

* E-mail: Amanda.Law@ucdenver.edu

Affiliations Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America, Department of Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora, Colorado, United States of America
⨯

PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia

Kristy R. Howell,
Kirsten Floyd,
Amanda J. Law

Published: May 3, 2017
https://doi.org/10.1371/journal.pone.0175993

About the Authors

Kristy R. Howell

Affiliation Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America

http://orcid.org/0000-0002-0872-5335

Kirsten Floyd

Affiliation Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America

Amanda J. Law

* E-mail: Amanda.Law@ucdenver.edu

Affiliations Department of Psychiatry, School of Medicine, University of Colorado, Aurora, Colorado, United States of America, Department of Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora, Colorado, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: AJL KRH. Data curation: AJL KRH KF. Formal analysis: AJL KRH KF. Funding acquisition: AJL. Investigation: AJL KRH KF. Methodology: AJL. Project administration: AJL KRH KF. Resources: AJL. Supervision: AJL. Validation: AJL. Visualization: AJL KRH. Writing – original draft: AJL KRH. Writing – review & editing: AJL KRH.

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Schizophrenia
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Mice
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Animal behavior
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Hippocampus
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Medical risk factors
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Mouse models
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Genetically modified animals
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Memory
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