About the Authors

Christina Grau

Contributed equally to this work with: Christina Grau, Molly Starkovich

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Molly Starkovich

Contributed equally to this work with: Christina Grau, Molly Starkovich

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Mahshid S. Azamian

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Fan Xia

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Baylor Genetics, Houston, Texas, Unite States of America

Sau Wai Cheung

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Baylor Genetics, Houston, Texas, Unite States of America

Patricia Evans

Affiliation Departments of Pediatrics and Neurology, University of Texas Southwestern Medical School, Dallas, Texas, United States of America

Alex Henderson

Affiliation The Newcastle upon Tyne Hospitals, Newcastle upon Tyne, England

Seema R. Lalani

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Daryl A. Scott

dscott@bcm.edu

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors of this manuscript have the following competing interests: DAS is a member of the Clinical Advisory Board of Baylor Genetics. The Department of Molecular and Human Genetics at Baylor College of Medicine derives revenue from genetic analyses offered through Baylor Genetics. Baylor Genetics did not play a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript and only provided financial support in the form of salaries for FX and SWC. These affiliations do not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors have declared that no competing interests exist.

Author Contributions

Conceptualization: CG MS FX SWC PE AH SRL DAS. Data curation: CG MS MSA FX SWC PE AH SRL DAS. Formal analysis: CG MS DAS. Funding acquisition: DAS. Investigation: CG MS MSA FX SWC PE AH SRL DAS. Methodology: CG MS DAS. Project administration: DAS. Resources: MSA FX SWC PE AH SRL DAS. Supervision: DAS. Validation: MS FX SWC PE AH SRL DAS. Visualization: CG MS SRL DAS. Writing – original draft: CG MS DAS. Writing – review & editing: CG MS MSA FX SWC PE AH SRL DAS.