About the Authors

Shigetoshi Yokoyama

Contributed equally to this work with: Shigetoshi Yokoyama, Soichi Furukawa, Shoya Kitada

Current address: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Affiliation Department of Systems Biomedicine, National Institute of Child Health and Development, Setagaya, Tokyo, Japan

Soichi Furukawa

Contributed equally to this work with: Shigetoshi Yokoyama, Soichi Furukawa, Shoya Kitada

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan

Shoya Kitada

Contributed equally to this work with: Shigetoshi Yokoyama, Soichi Furukawa, Shoya Kitada

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan

Masaki Mori

Current address: Department of Medical Chemistry, Molecular Neuroscience Research Center (MNRC), Shiga University of Medical Science, Otsu, Shiga, Japan

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan

Takeshi Saito

Affiliation Department of Systems Biomedicine, National Institute of Child Health and Development, Setagaya, Tokyo, Japan

Koichi Kawakami

Affiliation Division of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, SOKENDAI (The Graduate University for Advanced Studies), Mishima, Shizuoka, Japan

Juan Carlos Izpisua Belmonte

Affiliation Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

Yasuhiko Kawakami

Current address: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America

Affiliation Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

Yoshiaki Ito

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan

Tempei Sato

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan

Hiroshi Asahara

asahara.syst@tmd.ac.jp

Affiliations Department of Systems Biomedicine, National Institute of Child Health and Development, Setagaya, Tokyo, Japan, Department of Systems BioMedicine, Tokyo Medical and Dental University, Bunkyo, Tokyo, Japan, Department of Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: SY JCIB YK HA. Data curation: SY SF SK T. Sato HA. Formal analysis: SY SF SK T. Saito YI T. Sato HA. Funding acquisition: HA. Investigation: SY SF SK T. Saito YI T. Sato HA. Methodology: SY JCIB KK YK HA. Project administration: HA. Resources: SY KK YK HA. Software: SY SF MM. Supervision: HA. Validation: SY HA. Visualization: SY HA. Writing – original draft: SY SF YK HA. Writing – review & editing: KK T. Sato YI JCIB.