About the Authors

Beatriz P. Monteiro

Contributed equally to this work with: Beatriz P. Monteiro, Mary P. Klinck, Maxim Moreau

Affiliation GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada

Mary P. Klinck

Contributed equally to this work with: Beatriz P. Monteiro, Mary P. Klinck, Maxim Moreau

Affiliations GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada, Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Maxim Moreau

Contributed equally to this work with: Beatriz P. Monteiro, Mary P. Klinck, Maxim Moreau

Affiliations GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada, Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Martin Guillot

Affiliations GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada, Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Paulo V. M. Steagall

Affiliation Department of Clinical Sciences, Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada

Jean-Pierre Pelletier

Affiliation Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Johanne Martel-Pelletier

Affiliation Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Dominique Gauvin

Affiliation GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada

Jérôme R. E. del Castillo

Affiliation GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada

Eric Troncy

eric.troncy@umontreal.ca

Affiliations GREPAQ (Animal Pharmacology Research Group of Quebec), Faculty of Veterinary Medicine–Université de Montréal, Saint-Hyacinthe, QC, Canada, Osteoarthritis Research Unit, Research Center of the University of Montreal Hospital Centre, Montreal, QC, Canada

Competing Interests

The authors have the following interests. This study was partly supported by a Collaborative Research and Development grant (#RDCPJ 418399–2011, #RDCPJ 491953–2016, supporting operations and salaries) in partnership with ArthroLab Inc. from the Natural Sciences and Engineering Research Council of Canada. The Elanco sponsor was given the opportunity to review the manuscript and comment. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: ET JPP JMP. Data curation: MG JREdC. Formal analysis: MG JREdC. Funding acquisition: ET. Investigation: BPM MPK MM. Methodology: ET PVMS. Project administration: ET DG. Resources: DG BMS MPK MM JPP JMP ET. Supervision: ET PVMS JPP JMP JREdC. Validation: ET JREdC. Visualization: BMS MM ET. Writing – original draft: BMS ET. Writing – review & editing: BMS MPK MM MG PVMS JPP JMP DG JREdC ET.