About the Authors

Qurratul-Ain Dar

Contributed equally to this work with: Qurratul-Ain Dar, Eric M. Schott, Sarah E. Catheline

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Biology, University of Rochester, Rochester, New York, United States of America

Eric M. Schott

Contributed equally to this work with: Qurratul-Ain Dar, Eric M. Schott, Sarah E. Catheline

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

Sarah E. Catheline

Contributed equally to this work with: Qurratul-Ain Dar, Eric M. Schott, Sarah E. Catheline

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

Robert D. Maynard

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

Zhaoyang Liu

Affiliation Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America

Fadia Kamal

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Orthopaedics & Rehabilitation, University of Rochester Medical Center, Rochester, New York, United States of America

Christopher W. Farnsworth

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

John P. Ketz

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Orthopaedics & Rehabilitation, University of Rochester Medical Center, Rochester, New York, United States of America

Robert A. Mooney

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

Matthew J. Hilton

Affiliation Orthopaedic Cellular, Developmental & Genome Laboratories, Duke University, Durham, North Carolina, United States of America

Jennifer H. Jonason

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Orthopaedics & Rehabilitation, University of Rochester Medical Center, Rochester, New York, United States of America

Janne Prawitt

Affiliation Rousselot BVBA, Gent, Belgium

Michael J. Zuscik

michael_zuscik@urmc.rochester.edu

Affiliations Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Orthopaedics & Rehabilitation, University of Rochester Medical Center, Rochester, New York, United States of America

Competing Interests

A research contract was struck with Rousselot BVBA that provided partial financial support for the research that was performed in this study. Co-author Dr. Janne Prawitt, employee of Rousselot BVBA is a scientific contributor to the work, as delineated in the CRediT & Author Contributions section in the submission system. Prior to completion of peer review, a provisional patent was filed protecting intellectual property related to findings presented in this report. The research contract between Rousselot BVBA and the University of Rochester does not alter our adherence to PLOS ONE policies on sharing data and materials; i.e., there are no restrictions on sharing of data and/or materials.

Author Contributions

Conceptualization: JPK RAM MJH JHJ JP MJZ. Data curation: Q-AD EMS SEC RDM ZL FK CWF. Formal analysis: Q-AD EMS SEC RDM ZL FK CWF RAM JHJ MJZ. Funding acquisition: MJH JP MJZ. Investigation: Q-AD EMS SEC RDM ZL FK CWF. Project administration: JPK RAM MJH JHJ JP MJZ. Supervision: JPK RAM MJH JHJ JP MJZ. Validation: JPK RAM MJH JHJ MJZ. Visualization: MJZ. Writing – original draft: MJZ. Writing – review & editing: Q-AD EMS SEC RDM ZL FK CWF JPK RAM MJH JHJ JP MJZ.