About the Authors

Yutaka Saito

Affiliations Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Koto-ku, Tokyo, Japan, Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Shinjuku-ku, Tokyo, Japan, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama, Japan

Chie Sugimoto

Affiliation Department of Hygiene and Cellular Preventive Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

Toutai Mituyama

Affiliations Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Koto-ku, Tokyo, Japan, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama, Japan

Hiroshi Wakao

hwakao@dokkyomed.ac.jp

Current address: International epidemiology, Dokkyo Medical University, Shimotsuga-gun, Tochigi, Japan

Affiliation Department of Hygiene and Cellular Preventive Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: HW receives a research fund from Asubio Pharma Co., LTD for the data collection of DNA methylation in reMAITs. However, the funder had no role in data analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: HW. Data curation: YS CS TM HW. Formal analysis: YS TM. Funding acquisition: YS CS TM HW. Investigation: CS HW. Methodology: YS CS TM HW. Project administration: HW. Resources: CS HW. Supervision: HW. Validation: YS CS TM HW. Visualization: YS TM. Writing – original draft: YS CS TM HW.