About the Authors

Takahiro Tashiro

Affiliations Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan, Departmet of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Hiroaki Okuyama

Affiliation Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan

Hiroko Endo

Affiliation Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan

Kenji Kawada

Affiliation Departmet of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Yasuko Ashida

Affiliation Charles River Laboratories Japan, Yokohama, Kanagawa, Japan

Masayuki Ohue

Affiliation Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan

Yoshiharu Sakai

Affiliation Departmet of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, Japan

Masahiro Inoue

inoue-ma2@mc.pref.osaka.jp

Affiliation Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka, Japan

Competing Interests

YA is an employee of Charles River Laboratories Japan. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: TT MI. Formal analysis: TT MI. Funding acquisition: MI. Investigation: TT YA. Methodology: TT HO HE MI. Resources: TT YA MO MI. Supervision: KK YS MI. Validation: TT. Visualization: TT MI. Writing – original draft: TT MI. Writing – review & editing: HO HE KK YA MO YS MI.