About the Authors

Koyu Ito

koyu.ito.c6@tohoku.ac.jp (KI); hattori@ak.med.kyoto-u.ac.jp (MH)

Affiliations Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan, Department of Immunobiology, Institute of Development, Ageing, and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Akira Nakajima

Affiliation Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Yuji Fukushima

Affiliation Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Keiichiro Suzuki

Affiliation Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Keiko Sakamoto

Affiliation Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Yoko Hamazaki

Affiliation Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Kouetsu Ogasawara

Affiliation Department of Immunobiology, Institute of Development, Ageing, and Cancer, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan

Nagahiro Minato

Affiliation Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Masakazu Hattori

koyu.ito.c6@tohoku.ac.jp (KI); hattori@ak.med.kyoto-u.ac.jp (MH)

Affiliation Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, Japan

Competing Interests

This work was supported by Astellas Pharma Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: KI AN K. Suzuki YH NM MH. Formal analysis: KI AN YF K. Suzuki MH. Funding acquisition: KI MH. Investigation: KI YF K. Sakamoto. Methodology: KI AN K. Suzuki YH NM MH. Project administration: KI MH. Supervision: NM MH. Validation: KI AN YF K. Suzuki K. Suzuki MH. Writing – original draft: KI NM MH. Writing – review & editing: KI KO NM MH.