About the Authors
- Sean M. Bell
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* E-mail: sbell@bmrn.com
Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Dan J. Wendt
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Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Yanhong Zhang
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Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Timothy W. Taylor
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† Deceased.
Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Shinong Long
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Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Laurie Tsuruda
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Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Bin Zhao
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Current address: BioZ Consulting, San Ramon, California, United States of America
Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
- Phillip Laipis
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Affiliation Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America
- Paul A. Fitzpatrick
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Affiliation BioMarin Pharmaceutical, Novato, California, United States of America
Competing Interests
All authors except Dr. Laipis are employees of BioMarin Pharmaceutical Inc. BioMarin has funded all the studies and is developing rAvPAL-PEG for treatment of Phenylketonuria. The described study was a part of the drug development program at BioMarin. Patents regarding this approach and drug formulation have been filed. This does not alter the authors' adherence to PLoS ONE policies on sharing data and materials. The internal publication review committee approved the manuscript for publication.
Author Contributions
Conceptualization: PAF SMB DJW. Data curation: SMB LT PL PAF. Formal analysis: SMB BZ PL. Investigation: SMB DJW YZ SL LT BZ PL PAF. Methodology: SMB DJW BZ PAF PL. Project administration: PAF. Resources: SMB YZ TWT PL PAF. Supervision: PAF. Validation: PAF SMB LT PL. Visualization: SMB. Writing – original draft: SMB. Writing – review & editing: SMB PAF.