About the Authors

Gianluca Villa

gianlucavilla1@gmail.com

Affiliations Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy, Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Cosimo Chelazzi

Affiliations Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy, Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Elena Morettini

Affiliation Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy

Lucia Zamidei

Affiliation Anesthesia and Intensive Care Unit, Ospedale Santo Stefano, Prato, Italy

Serafina Valente

Affiliation Intensive Cardiac Coronary Unit, Heart and Vessel Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

A. Lucia Caldini

Affiliation Clinical Chemistry Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Giovanni Zagli

Affiliations Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy, Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

A. Raffaele De Gaudio

Affiliations Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy, Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Stefano Romagnoli

Affiliations Department of Health Science, Section of Anesthesiology and Intensive Care, University of Florence, Florence, Italy, Department of Anesthesia and Intensive Care, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

Competing Interests

We have the following interests: Baxter has provided a grant to the Department of Health Science of the University of Florence for the cytokine analysis. GV received from Baxter support for travel expenses, hotel accommodations, and registration to meetings. CC received honoraria for lectures by Orion Pharma; a grant for consultancy by Astellas; support for meetings (travel, hotel accommodations and/or registration) by BBraun, Astellas, MSD, Pfizer, Pall International, Baxter, Orion Pharma. ARDG received research grants from MSD Italia, Baxter, Pall international. SR received from Baxter, Orion Pharma, and Vygon honoraria for lectures, from ICU Medical, MSD and Medtronic grants for consultancy, from Baxter, BBraun, Pall International, and Vygon support for travel expenses, hotel accommodations, and registration to meetings. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: GV ARDG CC SR. Data curation: GV ALC. Formal analysis: GV ALC. Funding acquisition: ARDG. Investigation: GV CC SR EM LZ SV GZ. Methodology: GV ARDG CC SR. Project administration: GV. Supervision: ARDG. Validation: ARDG. Visualization: GV ARDG CC SR. Writing – original draft: GV. Writing – review & editing: GV ARDG CC SR.