Th40 cells (CD4+CD40+ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells

Gisela M. Vaitaitis; Martin G. Yussman; Dan M. Waid; David H. Wagner Jr.

doi:10.1371/journal.pone.0172037

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Open Access

Peer-reviewed

Research Article

Th40 cells (CD4⁺CD40⁺ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells

Gisela M. Vaitaitis,

Affiliations Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Webb-Waring Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Martin G. Yussman,

Affiliations Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Webb-Waring Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Dan M. Waid,

Affiliations Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Webb-Waring Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
David H. Wagner Jr.

* E-mail: david.wagner@ucdenver.edu

Affiliations Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Webb-Waring Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Th40 cells (CD4⁺CD40⁺ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells

Gisela M. Vaitaitis,
Martin G. Yussman,
Dan M. Waid,
David H. Wagner Jr.

Published: February 13, 2017
https://doi.org/10.1371/journal.pone.0172037

About the Authors

Gisela M. Vaitaitis

Affiliations Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America, Webb-Waring Center, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America

Martin G. Yussman

Dan M. Waid

David H. Wagner Jr.

* E-mail: david.wagner@ucdenver.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: DHW GMV. Data curation: GMV. Formal analysis: GMV. Funding acquisition: DHW. Investigation: GMV MGY DMW. Methodology: DHW GMV. Project administration: GMV. Resources: DHW. Supervision: DHW. Validation: DHW GMV. Visualization: GMV. Writing – original draft: GMV. Writing – review & editing: GMV DHW MGY DMW.

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T cells
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Spinal cord
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Cytokines
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Mouse models
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Spleen
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Cell staining
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Lymphocytes
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Central nervous system
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