Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver

I-Hsuan Lin; Yi-Fan Chen; Ming-Ta Hsu

doi:10.1371/journal.pone.0170779

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Open Access

Peer-reviewed

Research Article

Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver

I-Hsuan Lin,

Affiliations VYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan, The Center of Translational Medicine, Taipei Medical University, Taipei, Taiwan
⨯
Yi-Fan Chen,

Affiliations VYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan, The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
⨯
Ming-Ta Hsu

* E-mail: mth@ym.edu.tw

Affiliations Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan, Chien-Tien Hsu Cancer Research Foundation, Taipei, Taiwan
⨯

Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver

I-Hsuan Lin,
Yi-Fan Chen,
Ming-Ta Hsu

Published: January 26, 2017
https://doi.org/10.1371/journal.pone.0170779

About the Authors

I-Hsuan Lin

Affiliations VYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan, The Center of Translational Medicine, Taipei Medical University, Taipei, Taiwan

Yi-Fan Chen

Affiliations VYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan, The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Ming-Ta Hsu

* E-mail: mth@ym.edu.tw

Affiliations Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan, Chien-Tien Hsu Cancer Research Foundation, Taipei, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: MTH. Data curation: IHL. Formal analysis: IHL. Funding acquisition: MTH. Investigation: IHL YFC. Project administration: IHL MTH. Resources: IHL YFC. Software: IHL. Supervision: MTH. Validation: IHL YFC. Visualization: IHL. Writing – original draft: IHL. Writing – review & editing: IHL MTH.

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Gene expression
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Cerebellum
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DNA methylation
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Hypothalamus
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Thalamus
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Liver
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Hippocampus
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Gene regulation
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