About the Authors

Marjory B. Brooks

Affiliation Comparative Coagulation Section, Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, United States of America

James R. Turk

Affiliation Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, CA, United States of America

Abraham Guerrero

Affiliation Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, CA, United States of America

Padma K. Narayanan

Affiliation Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, CA, United States of America

John P. Nolan

Affiliation Scintillon Institute, San Diego, CA, United States of America

Elizabeth G. Besteman

Affiliation Department of Pathology, Safety Assessment and Laboratory Animal Resources, Merck Research Laboratories, West Point, PA, United States of America

Dennis W. Wilson

Affiliation Department of Pathology Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA, United States of America

Roberta A. Thomas

Affiliation GlaxoSmithKline, Research and Development, King of Prussia, Pennsylvania, United States of America

Cindy E. Fishman

Affiliation GlaxoSmithKline, Research and Development, King of Prussia, Pennsylvania, United States of America

Karol L. Thompson

Affiliation Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, United States of America

Heidrun Ellinger-Ziegelbauer

Affiliation Bayer Pharma AG, Aprather Weg,Wuppertal, Germany

Jennifer B. Pierson

Affiliation Health and Environmental Sciences Institute, Suite, Washington, DC, United States of America

April Paulman

Affiliation Department of Pathology, Covance Laboratories, Greenfield, IN, United States of America

Alan Y. Chiang

Affiliation Global Statistical Sciences, Lilly Research Laboratories, Indianapolis, IN, United States of America

Albert E. Schultze

aes@lilly.com

Affiliation Pathology Department, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, United States of America

Competing Interests

Lilly supported the in-life phase of this study by contracting for laboratories services, animals and reagents at the Covance facility in Greenfield, IN. All other work was provided in-kind by the ILSI HESI Cardiac Safety Committee Cardiac Biomarkers Working Group, which is supported by sponsorships from member companies. HESI’s scientific initiatives are primarily supported by the in-kind contributions (from public and private sector participants) of time, expertise, and experimental effort. These contributions are supplemented by direct funding (that primarily supports program infrastructure and management) provided primarily by HESI’s corporate sponsors. All authors are members of the ILSI HESI Cardiac Safety Committee Cardiovascular Biomarkers Working Group, a global non-profit organization. James R. Turk, Abraham Guerrero and Padma K. Narayanan are employed by Amgen Inc. Elizabeth G. Besteman is employed by Merck Research Laboratories. Roberta A. Thomas and Cindy E. Fishman are employed by GlaxoSmithKline. Heidrun Ellinger-Ziegelbauer is employed by Bayer Pharma AG. April Paulman is employed by Covance Laboratories. Alan Y. Chiang and Albert E. Schultze are employed by Lilly Research Laboratories. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: MBB JRT PKN AG JPN EGB DWW JBP AES. Data curation: MBB JRT AG PKN JPN RAT CEF KLT HE AES. Formal analysis: AYC AES CEF RAT JRT. Investigation: AYC AES CEF RAT JRT. Methodology: MBB JRT PKN AG JPN EGB DWW AP AYC AES. Project administration: AES MBB JBP. Resources: AES JPB RAT CEF KLT HE AP. Supervision: MBB AES JBP. Visualization: AES MBB JBP HE RAT CEF. Writing – original draft: MBB JRT JPN EGB DWW RAT CEG KLT HE JPB AP AYC AES. Writing – review & editing: MBB JRT AG PKN JPN EGB DWW RAT CEF KLT HE JBP AP AYC AES.