About the Authors

Alice C. O’Farrell

Contributed equally to this work with: Alice C. O’Farrell, Rhys Evans

Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Rhys Evans

Contributed equally to this work with: Alice C. O’Farrell, Rhys Evans

Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Johanna M. U. Silvola

Affiliation Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland

Ian S. Miller

Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Emer Conroy

Affiliation UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland

Suzanne Hector

Affiliations Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland, Roche Innovation Center Basel, F Hoffman La Roche, Basel, Switzerland

Maurice Cary

Affiliation Pathology Experts GmbH, Basel, Switzerland

David W. Murray

Affiliations Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland, Oncomark Ltd, Dublin, Ireland

Monika A. Jarzabek

Affiliations Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland, Roche Innovation Center Basel, F Hoffman La Roche, Basel, Switzerland

Ashwini Maratha

Affiliation Oncomark Ltd, Dublin, Ireland

Marina Alamanou

Affiliation Oncomark Ltd, Dublin, Ireland

Girish Mallya Udupi

Affiliation Oncomark Ltd, Dublin, Ireland

Liam Shiels

Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Celine Pallaud

Affiliation Roche Innovation Center Basel, F Hoffman La Roche, Basel, Switzerland

Antti Saraste

Affiliations Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland, Heart Center, Turku University Hospital and Åbo Akademi University, Turku, Finland

Heidi Liljenbäck

Affiliation Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland

Matti Jauhiainen

Affiliation Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland

Vesa Oikonen

Affiliation Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland

Axel Ducret

Affiliation Roche Innovation Center Basel, F Hoffman La Roche, Basel, Switzerland

Paul Cutler

Affiliation Roche Innovation Center Basel, F Hoffman La Roche, Basel, Switzerland

Fionnuala M. McAuliffe

Affiliation UCD Obstetrics & Gynaecology, School of Medicine, University College, Dublin, National Maternity Hospital, Dublin, Ireland

Jacques A. Rousseau

Affiliation Université de Sherbrooke, Québec, Canada

Roger Lecomte

Affiliation Université de Sherbrooke, Québec, Canada

Suzanne Gascon

Affiliation Université de Sherbrooke, Québec, Canada

Zoltan Arany

Affiliation Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, United States of America

Bonnie Ky

Affiliation Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, United States of America

Thomas Force

Affiliation Vanderbilt University School of Medicine, Nashville, United States of America

Juhani Knuuti

Affiliation Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland

William M. Gallagher

Affiliations UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland, Oncomark Ltd, Dublin, Ireland

Anne Roivainen

Affiliations Turku PET Centre, Turku University Hospital and Åbo Akademi University, Turku, Finland, Turku Center for Disease Modeling, University of Turku, Turku, Finland

Annette T. Byrne

annettebyrne@rcsi.ie

Affiliation Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

Competing Interests

There are no competing interests associated with the publication of this manuscript and the commercial affiliations do not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: ATB. Data curation: SH AD PC. Formal analysis: ACOF RE ISM DWM MAJ AM GMU MJ VO AD PC. Funding acquisition: ATB. Investigation: ACOF RE JMUS ISM EC SH MC DWM MAJ AM MA GMU LS AS HL MJ VO SG. Methodology: ATB RE ACOF JAR RL JK AR. Project administration: ATB. Resources: FMM WMG. Supervision: CP. Visualization: ACOF ATB. Writing – original draft: ACOF ISM DWM MAJ JMUS EC ATB. Writing – review & editing: ACOF ZA BK TF ATB.