About the Authors

Ling Li

Contributed equally to this work with: Ling Li, Hailong Zhang

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Hailong Zhang

Contributed equally to this work with: Ling Li, Hailong Zhang

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Man Zhang

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Mengxi Zhao

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Lijian Feng

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Xiao Luo

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Zhenting Gao

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Ying Huang

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Ophelia Ardayfio

Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Ji-Hu Zhang

Affiliation Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Ying Lin

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Hong Fan

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Yuan Mi

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Guobin Li

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Lei Liu

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Leying Feng

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Fangjun Luo

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Lin Teng

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Wei Qi

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Johannes Ottl

Affiliation Novartis Institutes for BioMedical Research, Basel, Switzerland

Andreas Lingel

Affiliation Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Dirksen E. Bussiere

Affiliation Novartis Institutes for BioMedical Research, Emeryville, California, United States of America

Zhengtian Yu

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Peter Atadja

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Chris Lu

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

En Li

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Justin Gu

Kehao.zhao@novartis.com (KZ); Justin.gu@novartis.com (JG)

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Kehao Zhao

Kehao.zhao@novartis.com (KZ); Justin.gu@novartis.com (JG)

Affiliation China Novartis Institutes for BioMedical Research, Shanghai, China

Competing Interests

L.Li, H.Z., M.Zhang., M.Zhao., Li.F., X.L., Z.G., Y.H., O.A., JH.Z., Y.L., H.F., Y.M., G.L., L.Liu., Le.F., F.L., L.T., W.Q., J.O., A.L., D.E. B., Z.Y., P.A.,C.L., E.L., J.G., and K.Z. are all employees of Novartis Institutes of BioMedical Research and may hold Novartis stock. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: KZ JG. Data curation: L. Li HZ M. Zhang M. Zhao XL ZG YH JHZ YL YM GL L. Liu WQ JO KZ JG. Investigation: KZ JG L. Li HZ M. Zhang M. Zhao XL ZG. Methodology: M. Zhang M. Zhao Lijian F. ZG OA HF GL L. Liu Leying F. FL LT JO. Resources: PA CL EL. Supervision: KZ JG. Writing – original draft: KZ. Writing – review & editing: L. Li HZ XL YH JHZ ZG ZY AL DEB.