About the Authors

Laurens J. Ceulemans

Contributed equally to this work with: Laurens J. Ceulemans, Len Verbeke

ceulemans.laurens@gmail.com

Affiliation Abdominal Transplant Surgery, University Hospitals Leuven, & Department of Microbiology and Immunology, KU Leuven, Belgium

Len Verbeke

Contributed equally to this work with: Laurens J. Ceulemans, Len Verbeke

Affiliation Liver and Biliopancreatic Disorders, University Hospitals Leuven, KU Leuven, Belgium

Jean-Paul Decuypere

Affiliation Abdominal Transplant Surgery, University Hospitals Leuven, & Department of Microbiology and Immunology, KU Leuven, Belgium

Ricard Farré

Affiliation Gastro-enterology, University Hospitals Leuven, & Translational Research in Gastro-Intestinal Disorders (TARGID), KU Leuven, Belgium

Gert De Hertogh

Affiliation Translational Cell and Tissue Research, University Hospitals Leuven, & Department of Imaging and Pathology, KU Leuven, Belgium

Kaatje Lenaerts

Affiliation Department of Surgery, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands

Ina Jochmans

Affiliation Abdominal Transplant Surgery, University Hospitals Leuven, & Department of Microbiology and Immunology, KU Leuven, Belgium

Diethard Monbaliu

Affiliation Abdominal Transplant Surgery, University Hospitals Leuven, & Department of Microbiology and Immunology, KU Leuven, Belgium

Frederik Nevens

Affiliation Liver and Biliopancreatic Disorders, University Hospitals Leuven, KU Leuven, Belgium

Jan Tack

Affiliation Gastro-enterology, University Hospitals Leuven, & Translational Research in Gastro-Intestinal Disorders (TARGID), KU Leuven, Belgium

Wim Laleman

Affiliation Liver and Biliopancreatic Disorders, University Hospitals Leuven, KU Leuven, Belgium

Jacques Pirenne

Affiliation Abdominal Transplant Surgery, University Hospitals Leuven, & Department of Microbiology and Immunology, KU Leuven, Belgium

Competing Interests

Frederik Nevens, co-author of this manuscript, has the following competing interest: he is an advisory board member of Intercept Pharma®. J. Pirenne received grants from commercial resources (Astellas and Roche) in support of attending scientific conferences. These grants were unrelated to the study on FXR-agonism and the presented data. There are no additional patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: LJC LV JPD RF GDH KL WL JP. Data curation: LJC LV JPD JP. Formal analysis: LJC LV JPD RF GDH KL FN JT WL JP. Funding acquisition: KL IJ DM FN JT WL JP. Investigation: LJC LV JPD RF GDH IJ DM JP. Methodology: LJC LV JPD RF GDH KL IJ DM FN JT WL JP. Project administration: LJC LV JPD RF JP. Resources: LJC LV JPD RF GDH KL IJ DM FN JT WL JP. Software: JPD RF. Supervision: FN JT WL JP. Validation: LJC LV JPD RF GDH WL JP. Visualization: LJC LV JPD RF GDH KL JP. Writing – original draft: LJC LV JPD RF KL WL JP. Writing – review & editing: LJC LV JPD RF GDH KL IJ DM FN JT WL JP.