About the Authors

Yuhzo Fujita

Affiliation Yuno Onsen Hospital, Yuno, Syunan-shi, Yamaguchi, Japan

Haruo Tsuno

Affiliation Yuno Onsen Hospital, Yuno, Syunan-shi, Yamaguchi, Japan

Jiro Nakayama

nakayama@agr.kyushu-u.ac.jp

Affiliation Laboratory of Microbial Technology, Division of Systems Bioengineering, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Hakozaki, Higashi-ku, Fukuoka, Japan

Competing Interests

SAIDO Co., Ltd. provided funding support for this study. There are no other conflicts of interest or declarations. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: YF. Data curation: YF. Formal analysis: YF JN. Investigation: YF HT JN. Methodology: YF JN. Project administration: YF. Software: YF JN. Supervision: YF. Validation: YF JN. Visualization: YF JN. Writing – original draft: YF JN. Writing – review & editing: YF JN.