About the Authors

Manami Kaneko

manami.kaneko@takeda.com

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Kentarou Hashikami

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Satoshi Yamamoto

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Hirokazu Matsumoto

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Tomoyuki Nishimoto

Affiliation Cardiovascular and Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Competing Interests

All authors are employees of Takeda Pharmaceutical Company Limit. All materials and compounds used in this study are commercially available. There are no patents and products in development or market products to declare. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: MK. Formal analysis: MK TN. Investigation: MK KH SY. Methodology: MK KH SY. Project administration: HM TN. Validation: TN. Visualization: MK KH. Writing – original draft: MK KH. Writing – review & editing: TN.