About the Authors

Liangxian Cao

lcao@ptcbio.com

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Marla Weetall

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Jenelle Bombard

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Hongyan Qi

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Tamil Arasu

Current address: US Food and Drug Administration, Parsippany, New Jersey, United States of America

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

William Lennox

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Jean Hedrick

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Josephine Sheedy

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Nicole Risher

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Peter C. Brooks

Affiliation Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, Maine, United States of America

Panayiota Trifillis

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Christopher Trotta

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Young-Choon Moon

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

John Babiak

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Neil G. Almstead

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Joseph M. Colacino

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Thomas W. Davis

Current address: PMV Pharmaceuticals Inc., Cedar Brook Corporate Center, Cranbury Township, New Jersey, United States of America

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Stuart W. Peltz

Affiliation PTC Therapeutics, Inc., South Plainfield, New Jersey, United States of America

Competing Interests

We have the following interests: The authors are employed by and received monetary compensation from PTC Therapeutics, Inc. Liangxian Cao, Marla Weetall, Jenelle Bombard (former employee), Hongyan Qi (former employee), Tamil Arasu (former employee), William Lennox, Jean Hedrick, Josephine Sheedy, Nicole Risher, Panayiota Trifillis, Christopher Trotta, Young-Choon Moon, John Babiak, Neil G Almstead, Joseph M Colacino, Thomas W Davis (former employee) and Stuart W Peltz are or were employed by and hold or held financial interests in PTC Therapeutics, Inc. PTC Therapeutics hold the patents pertaining to the results presented in this paper as below: Liangxian Cao and Panayiota Trifillis, Methods for Identifying Compounds that Modulate Untranslated Region-Based Regulation, CA2514184 and US8460864. Christopher R Trotta and Liangxian Cao, Methods and Agents for Screening for Compounds Capable of Modulating VEGF Expression, CA2567111, EP2400038 and US8426194. Liangxian Cao; William Lennox; Hongyan Qi; Young-Choon Moon and Nadarajan Tamilarasu, Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis, MX286760 and US8940896. Young-Choon Moon; William Lennox and Hongyan Qi, Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control, US8946444 and US9271960. There are no additional patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: LC MW CT YM J. Babiak NA JC TD SP. Data curation: LC MW PB PT YM. Formal analysis: LC MW PB CT YM TD. Funding acquisition: JC LC PT YM MW TD. Investigation: LC J. Bombard HQ TA WL JH JS NR PB. Methodology: LC MW J. Bombard HQ TA WL JH JS NR PB. Project administration: LC MW PB CT YM J. Babiak NA JC TD SP. Supervision: LC MW PB YM J. Babiak NA JC TD SP. Validation: LC MW J. Bombard HQ TA WL JH JS NR PB. Writing – original draft: LC MW CT TD. Writing – review & editing: LC MW PB CT J. Babiak NA JC TD SP.