Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

So Youn Park; Hae Young Kim; Hee Jeong Park; Hwa Kyoung Shin; Ki Whan Hong; Chi Dae Kim

doi:10.1371/journal.pone.0168286

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Research Article

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

So Youn Park ,

Contributed equally to this work with: So Youn Park, Hae Young Kim

Affiliations Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯
Hae Young Kim ,

Contributed equally to this work with: So Youn Park, Hae Young Kim

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯
Hee Jeong Park,

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯
Hwa Kyoung Shin,

Affiliation Division of Meridian and Structural Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯
Ki Whan Hong,

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯
Chi Dae Kim

* E-mail: chidkim@pusan.ac.kr

Affiliations Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea
⨯

Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

So Youn Park,
Hae Young Kim,
Hee Jeong Park,
Hwa Kyoung Shin,
Ki Whan Hong,
Chi Dae Kim

Published: December 15, 2016
https://doi.org/10.1371/journal.pone.0168286

About the Authors

So Youn Park

Contributed equally to this work with: So Youn Park, Hae Young Kim

Affiliations Department of Pharmacology, School of Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea

Hae Young Kim

Contributed equally to this work with: So Youn Park, Hae Young Kim

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea

Hee Jeong Park

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea

Hwa Kyoung Shin

Affiliation Division of Meridian and Structural Medicine, Pusan National University, Gyeongsangnam-do, Republic of Korea

Ki Whan Hong

Affiliation Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, Republic of Korea

Chi Dae Kim

* E-mail: chidkim@pusan.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: KWH CDK. Data curation: HYK HKS. Investigation: SYP HYK HJP. Writing – original draft: KWH SYP HYK. Writing – review & editing: KWH SYP CDK.

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