About the Authors

Nadine Dietrich

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Matthias Kolibabka

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Stephanie Busch

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Petra Bugert

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Ulrike Kaiser

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Jihong Lin

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Thomas Fleming

Affiliation Department of Medicine I, University of Heidelberg, Heidelberg, Germany

Michael Morcos

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Thomas Klein

Affiliation Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma, Biberach, Germany

Andrea Schlotterer

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Hans-Peter Hammes

hp.hammes@umm.de

Affiliation 5th Medical Department, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany

Competing Interests

This work was supported by a grant from Boehringer Ingelheim. S.B. is recipient of a stipend from the Deutsche Forschungsgemeinschaft (International Research Training group 880 Vascular Medicine). T.K. is employed by Boehringer-Ingelheim. H.P.H. has received speaker’s honorarium and a travel grant from Boehringer-Ingelheim. No other potential conflicts of interest relevant to this article were reported. Our commercial affiliation involved provision of linagliptin, measurement of DPP-4 activity and GLP-1 levels by Boehringer Ingelheim. We believe that provision of these services did not influence the integrity of our work or alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: ND MM TK AS HPH. Data curation: ND TK. Formal analysis: ND MK SB JL TF TK AS HPH. Funding acquisition: TK HPH. Investigation: ND MK SB JL TK AS HPH. Methodology: ND PB UK TF TK AS. Project administration: ND TK HPH. Resources: ND SB JL TF TK AS. Supervision: ND MM TK HPH. Validation: MM TK AS HPH. Visualization: ND MK SB JL TF MM TK AS HPH. Writing – original draft: ND MM TK AS HPH. Writing – review & editing: ND MK SB JL TF MM TK AS HPH.