About the Authors

Leigh M. Howard

Contributed equally to this work with: Leigh M. Howard, Kristen L. Hoek, Johannes B. Goll

Affiliation Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Kristen L. Hoek

Contributed equally to this work with: Leigh M. Howard, Kristen L. Hoek, Johannes B. Goll

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Johannes B. Goll

Contributed equally to this work with: Leigh M. Howard, Kristen L. Hoek, Johannes B. Goll

Affiliation The Emmes Corporation, Rockville, MD, United States of America

Parimal Samir

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Allison Galassie

Affiliation Department of Chemistry, Vanderbilt University, Nashville, TN, United States of America

Tara M. Allos

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Xinnan Niu

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Laura E. Gordy

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America

C. Buddy Creech

Affiliation Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Nripesh Prasad

Affiliation HudsonAlpha Institute for Biotechnology; Huntsville, AL, United States of America

Travis L. Jensen

Affiliation The Emmes Corporation, Rockville, MD, United States of America

Heather Hill

Affiliation The Emmes Corporation, Rockville, MD, United States of America

Shawn E. Levy

Affiliation HudsonAlpha Institute for Biotechnology; Huntsville, AL, United States of America

Sebastian Joyce

Affiliations Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, United States of America

Andrew J. Link

kathryn.edwards@vanderbilt.edu (KME); andrew.link@vanderbilt.edu (AJL)

Affiliation Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Kathryn M. Edwards

kathryn.edwards@vanderbilt.edu (KME); andrew.link@vanderbilt.edu (AJL)

Affiliation Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States of America

Competing Interests

KME has received grant funding for group B streptococcal vaccine research from Novartis and has participated as a member on a Novartis Data Safety Monitoring Board on influenza vaccines. CBC has received institutional grant support for staphylococcal vaccine research from Pfizer and Novartis Vaccines. JBG, TJL, and HH are employed by The Emmes Corporation. The Emmes Corporation is an independent contract research organization NIH-NIAID-DMID contracted with for collecting and analyzing data for clinical trials and studies to evaluate the safety and efficacy of vaccines, devices, and therapeutics for infectious diseases. The Emmes Corporation does not have any patents, products in development or marketed products to declare. These affiliations do not alter our adherence to PLOS ONE policies on sharing data and materials; however, we have not released raw sequencing data to maintain accordance with subject confidentiality requirements as outlined in the study’s Informed Consent Document, as approved by the Vanderbilt University Medical Center Institutional Review Board. The other authors declare that they have no conflicts of interest.

Author Contributions

Conceptualization: SJ AJL KME. Data curation: JBG XN TLJ HH AJL. Formal analysis: JBG TLJ HH. Funding acquisition: AJL KME. Investigation: LMH KLH PS AG TMA LEG NP SEL AJL KME. Methodology: LMH KLH JBG AG NP TLJ HH SEL SJ AJL KME PS. Project administration: LMH KLH SEL AJL KME. Resources: CBC AJL KME. Software: JBG XN TLJ HH PS AJL KME. Supervision: AJL KME. Validation: JBG XN TLJ HH. Visualization: LMH KLH JBG TLJ HH AJL KME. Writing – original draft: LMH KLH JBG. Writing – review & editing: LMH KLH JBG PS AG TMA LEG CBC NP TLJ HH SEL SJ AJL KME XN.