Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor

Nasser B. Alsaleh; Indushekhar Persaud; Jared M. Brown

doi:10.1371/journal.pone.0167366

Loading metrics

Open Access

Peer-reviewed

Research Article

Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor

Nasser B. Alsaleh,

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Indushekhar Persaud,

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Jared M. Brown

* E-mail: jared.brown@ucdenver.edu.

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor

Nasser B. Alsaleh,
Indushekhar Persaud,
Jared M. Brown

Published: December 1, 2016
https://doi.org/10.1371/journal.pone.0167366

About the Authors

Nasser B. Alsaleh

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

Indushekhar Persaud

Jared M. Brown

* E-mail: jared.brown@ucdenver.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: JMB. Formal analysis: NBA. Funding acquisition: JMB. Investigation: NBA IP. Methodology: JMB NBA IP. Project administration: JMB. Resources: JMB. Supervision: JMB. Validation: NBA. Visualization: NBA. Writing – original draft: NBA. Writing – review & editing: NBA IP JMB.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mast cells
Is the Subject Area "Mast cells" applicable to this article?

Thanks for your feedback.
Cell degranulation
Is the Subject Area "Cell degranulation" applicable to this article?

Thanks for your feedback.
Calcium signaling
Is the Subject Area "Calcium signaling" applicable to this article?

Thanks for your feedback.
Calcium channels
Is the Subject Area "Calcium channels" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Membrane receptor signaling
Is the Subject Area "Membrane receptor signaling" applicable to this article?

Thanks for your feedback.
Signal transduction
Is the Subject Area "Signal transduction" applicable to this article?

Thanks for your feedback.
Signaling molecules
Is the Subject Area "Signaling molecules" applicable to this article?

Thanks for your feedback.