Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

Benjamin M. Ford; Lirit N. Franks; Anna Radominska-Pandya; Paul L. Prather

doi:10.1371/journal.pone.0167240

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Open Access

Peer-reviewed

Research Article

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

Benjamin M. Ford,

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America
⨯
Lirit N. Franks,

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America
⨯
Anna Radominska-Pandya,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America
⨯
Paul L. Prather

* E-mail: PratherPaulL@uams.edu

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America
⨯

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development

Benjamin M. Ford,
Lirit N. Franks,
Anna Radominska-Pandya,
Paul L. Prather

Published: December 9, 2016
https://doi.org/10.1371/journal.pone.0167240

About the Authors

Benjamin M. Ford

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America

Lirit N. Franks

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America

Anna Radominska-Pandya

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America

Paul L. Prather

* E-mail: PratherPaulL@uams.edu

Affiliation Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: BMF PLP AR. Data curation: BMF PLP. Formal analysis: BMF PLP. Funding acquisition: PLP. Investigation: BMF LNF PLP. Methodology: BMF LNF PLP. Project administration: PLP AR. Resources: PLP. Supervision: PLP. Validation: BMF PLP. Visualization: BMF PLP. Writing – original draft: BMF PLP. Writing – review & editing: BMF PLP.

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Isomers
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Adenylyl cyclase
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Cannabinoids
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Cancer treatment
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Drug therapy
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Drug research and development
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Adverse events
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Breast cancer
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